Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7509294 | Drug and Alcohol Dependence | 2009 | 7 Pages |
Abstract
The inverse relationship between prefrontal paralimbic rCBF and depression scores suggests a link between reduced fronto-limbic activity and depressive symptoms in MM patients. A significant subgroup of opiate-dependent patients has clinical or sub-clinical depression that is often undetected; our data identify brain substrates of depression symptoms that may also be a potential marker of relapse in this population. Treatment strategies targeting these brain regions may improve outcomes in depressed substance abusers.
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Authors
Jesse J. Suh, Daniel D. Langleben, Ronald N. Ehrman, Jonathan G. Hakun, Ze Wang, Yin Li, Samantha I. Busch, Charles P. O'Brien, Anna Rose Childress,