Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7557005 | Analytical Biochemistry | 2018 | 5 Pages |
Abstract
Microsampling is an attractive option for significantly reducing the volume of blood taken for chemical analysis allowing for blood samples taken as a 'finger-prick' with a lancet. A novel, volumetric adsorptive microsampling (VAMSâ¢) device, which reproducibly collects a small volume of 10â¯Î¼L whole blood in a hematocrit-independent manner, is evaluated in a human biomonitoring setting, and has been utilized for analysis of several perfluoroalkyl acids (PFAA). The results show that the VAMS technique is applicable for PFAA analysis, method has good linearity, repeatability, accuracy and is sufficiently sensitive for samples from general populations. The stability of PFAAs with VAMS devices is shown to be acceptable, which supports the sampling and transportation strategy of several study designs. Furthermore, as well as allowing for a quick and efficient extraction and analysis flow path, the VAMS microsampler is an easy to use device in a real-world sample collection scenario.
Keywords
volumetric absorptive microsamplingPerfluorotetradecanoic acidPerfluoroheptanoic acidNBCSPFDoAPFDAPFNAPFAAPFHpSSRMPFHxAPFHxSLiquid chromatography-triple quadrupole mass spectrometryperfluorododecanoic acidPFHpAperfluorohexanesulfonic acidPFOSPFOAperfluorohexanoic acidLOQperfluorotridecanoic acidRSDLC-MS/MSLC–MS/MSenvironmental pollutantperfluorodecanoic acidPerfluorononanoic acidPerfluoroundecanoic acidPerfluoroalkyl acidsrelative standard deviationBiomonitoringRoom temperaturelimit of quantitationselected reaction monitoringPerfluorooctanoic acid
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Jani Koponen, James Rudge, Stuart Kushon, Hannu Kiviranta,