| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7558822 | Analytical Biochemistry | 2014 | 7 Pages |
Abstract
Using an ultrasensitive chemically reduced graphene oxide and ionic liquid modified glass carbon electrode (RGI-GCE), separated electrochemical signals of adenine and hypoxanthine in both human breast cancer (MCF-7) and mouse embryonic fibroblast (BALB/3T3) cells were observed. For the first time, low-level expression of purine bases in noncancerous BALB/3T3 cells can be electrochemically monitored. The metabolism of purine bases in carcinogen agent-contaminated BALB/3T3 cells was also investigated through the change of electrochemical signals ascribed to different purine bases, which opens a new electrochemical approach to the exploration of a low-level purine mechanism in noncancerous cells.
Related Topics
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Authors
Guang-Gang Gao, Guo-Biao Xu, Jin-Lian Li, Ji-Wen Cui, Dong-Mei Wu, Hong-Bin Qiu,