| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7561122 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2011 | 9 Pages |
Abstract
⺠Ari1p reduces furan aldehydes to their less toxic alcohols in yeast. ⺠At equilibrium, reactions favor the alcohol and NADP+. ⺠Keq [NADP+][furfuryl alcohol]/[NADPH][furfural][H+] = 5600 x 107 M-1. ⺠Catalyzed reactions are equilibrium ordered: NADPH binds first and NADP+ leaves last. ⺠Microscopic rate constants indicate release of products is 84% rate-limiting to kcat.
Keywords
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Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Douglas B. Jordan, Jay D. Braker, Michael J. Bowman, Karl E. Vermillion, Jaewoong Moon, Z. Lewis Liu,