| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7561211 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2011 | 10 Pages |
Abstract
⺠Notch4ICD acts in concert with TGF-β pathway to drive fibrotic signaling. ⺠Proteomics studies indicate Notch4ICD and elongin C interact. ⺠Functional studies show elongin C inhibits Notch4-mediated TGF-β fibrotic activity. ⺠Elongin C negatively regulates Notch4ICD in a proteasome dependent manner. ⺠Elongin C is minimally expressed in type 1 diabetic renal proximal tubule cells.
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Authors
Timothy D. Cummins, Michael D. Mendenhall, Michelle N. Lowry, Erik A.Korte, Michelle T. Barati, Syed J. Khundmiri, Sarah A. Salyer, Jon B. Klein, David W. Powell,