Synthesis and biological activity of 5‑bromo‑2-chloropyrimidin-4-amine derivatives

A series of novel 5‑bromo‑2-chloropyrimidin-4-amine derivatives (7a‐h and 8a‐e) were synthesized by nucleophilic substitution reaction with various sulfonyl and acid chlorides. The newly synthesized compounds were characterized by elemental analyses, FT‐IR, 1H NMR and LC‐MS spectral studies. All compounds were evaluated for its in vitro antibacterial and antifungal activities. The Compound N-(5‑bromo‑2‑chloro‑pyrimidin-4-yl)-4-methyl-benzenesulfonamide (7b) exhibited significant antimicrobial activity against tested pathogenic bacterial and fungal strains.