| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7584790 | Food Chemistry | 2018 | 9 Pages |
Abstract
Antioxidant and cytocompatible chemically modified polysaccharides and their hydrogels were obtained by a biomimetic approach. For this purpose, carboxymethylpullulan grafted with ferulic acid (CMP-FA) was firstly synthesized with different substitution degrees (DSFA). Their hydrogels were secondly obtained by enzymatic cross-linking with laccase. Hydrogel swelling has been found dependent on both DSFA and media ionic strength. The CMP-FA antioxidant properties were evaluated by the DPPH method and ABTS assays. The DPPH radical scavenging effect was high for CMP-FA solutions (80% after 30â¯min) and lower for the corresponding hydrogels (70% after 7â¯h). The antibacterial properties of ferulic acid and CMP-FA derivatives were tested against Staphylococcus aureus but the minimal inhibitory concentration of CMP-FA was not reached in the range of concentrations studied. Finally the CMP-FA derivatives showed no cytotoxicity towards mouse fibroblast cells.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Virginie Dulong, Marie-Carole Kouassi, Béatrice Labat, Didier Le Cerf, Luc Picton,