Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7586164 | Food Chemistry | 2018 | 18 Pages |
Abstract
Bioactive peptides are oligopeptides that consist of 2-20 amino acids that can exert beneficial effects on human health in addition to basic nutritional effects. Food derived protein hydrolysates or peptides with immunomodulatory and anticancer activities have been reported from a variety of food protein sources such as milk, egg, fish, rice, soybean, pea, chlorella, spirulina, oyster and mussel. In vitro hydrolysis of food proteins using commercial proteolytic enzymes is the most commonly employed process for the production of immunomodulatory and anticancer food protein hydrolysates. The immunomodulatory and anticancer activities of food derived protein hydrolysates or peptides are related to the amino acid composition, sequence and length. Most immunomodulatory and anticancer food protein hydrolysates or peptides were tested using cell culture and animal models, while a few involved clinical trials. This review provides a comprehensive overview of immunomodulatory and anticancer food derived protein hydrolysates or peptides, their production and mechanisms of action.
Keywords
PBMCCOX-2ACEIC50kDakiloDaltonCCL18Bcl-2CDK2ERKConcanavalin AFITCiNOSDMBATGF-βLPSOVANF-κBsRBCsFACSPGE2s-IgAIFN-γ7,12-Dimethylbenz[a]anthraceneDNAMAPKsMTTangiotensin converting enzymeenzyme linked immunosorbent assayAcridine orangeethidium bromidedeoxyribonucleic acidOvalbuminimmunoglobulin interferon-γinterleukinCon-ABaxBADTransforming Growth Factor BetaOvomucoidELISAtumor necrosis factor-alphacluster of differentiationdaltondegree of hydrolysisfluorescence-activated cell sortingCarbon dioxideWorld Health OrganizationPeripheral blood mononuclear cellB cellsTH cellsT cellsT helper cellsNK cellsTreg cellsNatural killer cellsRegulatory T cellsinducible nitric oxide synthasecyclin-dependent kinase 2inhibitory concentration 50TNF-αnuclear factor kappa-light-chain-enhancer of activated B cellsPhosphatidylserinefluorescein isothiocyanateLactoferricinB lymphocytesT lymphocytesB-cell lymphoma 2lysozymeLYSlipopolysaccharidemajor histocompatibility complexMHCBcl-2-associated death promoterMechanisms of actionNitric oxideMolecular weightBCL2-associated X proteinPropidium iodideProstaglandin E2Anticancer peptidesCO2WHOExtracellular signal–regulated kinasemitogen-activated protein kinasessheep red blood cells
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Meram Chalamaiah, Wenlin Yu, Jianping Wu,