Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7586423 | Food Chemistry | 2018 | 25 Pages |
Abstract
Ferulic, caffeic, sinapic, and coumaric acids, belonging to the class of hydroxycinnamic acids (HAs), are bioactive polyphenols widespread in the plant kingdom and present in the human diet. Due to their biological properties and effects in the prevention of various diseases associated with oxidative stress, HAs can be exploited for attractive nutraceutical applications. Starting from this and in order to increase bioaccessibility, we encapsulated HAs in lipid-core nanocapsules (NCs) based on a biodegradable and biocompatible poly(ε-caprolactone) polymer. The results showed that nanoparticles loaded with hydroxycinnamic acids (HA-NCs) have diameter of 224-253â¯nm, encapsulation efficiency of 53-78%, and are stable over time (30â¯days). In vitro tests evidenced that NCs are able to preserve HAs in the gastric simulated fluid and release them in the intestinal simulated fluid. The delivery system developed could be employed to create novel functional foods.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Giuseppe Granata, Grazia M.L. Consoli, Raffaella Lo Nigro, Corrada Geraci,