Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7587229 | Food Chemistry | 2017 | 8 Pages |
Abstract
Heracleum dissectum Ledeb. has long been used as a wild edible vegetable by local people in China. The purpose of this study is to investigate the antidiabetic potential of aerial part of H. dissectum methanol extract (HdME) and the chemical constituents. Ten compounds including eight coumarins were isolated and four of them were found from H. dissectum for the first time. HdME potently inhibited the elevation of plasma glucose after its oral administration to glucose-loaded mice, and its petroleum ether (PE) fraction exerted the greatest inhibitory activities. Meanwhile, HdME (125 and 250 mg/kg) also significantly decreased the blood glucose level in STZ-induced diabetic mice, but had no effect in normoglycemic mice. Additionally, HdME showed weak inhibitory effects on α-glucosidase activity and DPPH free radicals scavenging. In conclusion, HdME has antidiabetic action and PE fraction is the active part where coumarins possibly play an important role in antidiabetic activity.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Hailong Zhang, Yaping Su, Xinrui Wang, Jie Mi, Yayu Huo, Zhigang Wang, Ying Liu, Yang Gao,