Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7588577 | Food Chemistry | 2016 | 7 Pages |
Abstract
Lutein is a carotenoid with antioxidant activity that is present in various dosage forms. The bioavailability of carotenoid from oral dosage formulations depends on their release, dissolution and its permeability through the gastrointestinal tract. Here, a dissolution test was developed for evaluating formulations and the bioavailability was assessed. The test utilized a USP-apparatus II with rotations of 50, 75 and 100Â rpm in water with P80 at 1, 2 and 5% (w/v). A non-everted rat intestinal sac model was used in conjunction to assess the intestinal permeability. The most discriminative conditions were 100Â rpm in water with 2% polysorbate 80, which showed profile differences between two formulations. The intestinal permeation studies showed a lag-time and apparent permeability coefficient that were characteristic of highly permeable drugs. We suggest that a dissolution test can be an essential quality control tool for formulations containing compounds as lutein, although not mandatory by the regulation agencies.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Carina de Souza Anselmo, Thamara de Carvalho Mendes, Thiago da Silva Honorio, Flávia Almada do Carmo, Lucio Mendes Cabral, Valeria Pereira de Sousa,