Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7589157 | Food Chemistry | 2016 | 7 Pages |
Abstract
Quercetin-3-O-rutinoside (rutin), quercetin-3-O-glucoside (isoquercetin) and quercetin have shown antioxidant, cytoprotective, vasoprotective, antiproliferative and antiinflammatory properties. The aim of this work was to determine the conversion of rutin to isoquercetin and quercetin during the production of poly(l-lactic acid) films with potential to deliver these flavonoids toward tissues, pharmaceuticals or food matrices. Three poly(l-lactic acid) formulations with 17.7, 39.6 and 39.1 mg/g of rutin were prepared by the extrusion process. Processing temperatures (130-165 °C) promoted the deglycosylation of rutin to produce isoquercetin and subsequently quercetin, identified by high performance liquid chromatography coupled to mass spectrometry. The effect of the process on the antioxidant activity of the films was determined by measuring the capacity to scavenge 2,2 diphenyl-1-picrylhydrazyl radicals. The material with the highest proportion of quercetin showed the highest antioxidant activity which could be used to produce delivering devices of the flavonoids to tissues, pharmaceuticals or food matrices.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Johana M. Cruz-Zúñiga, Herlinda Soto-Valdez, Elizabeth Peralta, Ana MarÃa Mendoza-Wilson, M. Refugio Robles-Burgueño, Rafael Auras, Nohemà Gámez-Meza,