Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7595895 | Food Chemistry | 2014 | 7 Pages |
Abstract
[6]-Gingerol and [6]-shogaol are the major pungent components in ginger with a variety of biological activities including antioxidant activity. To explore their structure determinants for antioxidant activity, we synthesized eight compounds differentiated by their side chains which are characteristic of the C1-C2 double bond, the C4-C5 double bond or the 5-OH, and the six- or twelve-carbon unbranched alkyl chain. Our results show that their antioxidant activity depends significantly on the side chain structure, the reaction mediums and substrates. Noticeably, existence of the 5-OH decreases their formal hydrogen-transfer and electron-donating abilities, but increases their DNA damage- and lipid peroxidation-protecting abilities. Additionally, despite significantly reducing their DNA strand breakage-inhibiting activity, extension of the chain length from six to twelve carbons enhances their anti-haemolysis activity.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Dong-Liang Lu, Xiu-Zhuang Li, Fang Dai, Yan-Fei Kang, Yan Li, Meng-Meng Ma, Xiao-Rong Ren, Gao-Wei Du, Xiao-Ling Jin, Bo Zhou,