Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7597633 | Food Chemistry | 2014 | 32 Pages |
Abstract
Curcumin has been shown to have a wide variety of biological activities for various human diseases including inflammation, diabetes and cancer. However, the poor oral bioavailability of curcumin poses a significant pharmacological barrier to its use therapeutically and/or as a functional food. Here we report the evaluation of the bioavailability and bio-efficacy of curcumin as an amorphous solid dispersion (ASD) in a matrix consisting of hydroxypropyl methyl cellulose (HPMC), lecithin and isomalt using hot melt extrusion for application in food products. Oral pharmacokinetic studies in rats showed that ASD curcumin was â¼13-fold more bioavailable compared to unformulated curcumin. Evaluation of the anti-inflammatory activity of ASD curcumin in vivo demonstrated enhanced bio-efficacy compared to unformulated curcumin at 10-fold lower dose. Thus ASD curcumin provides a more potent and efficacious formulation of curcumin which may also help in masking the colour, taste and smell which currently limit its application as a functional food ingredient.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Ai Mey Chuah, Bindya Jacob, Zhang Jie, Subbarayan Ramesh, Shibajee Mandal, Jithesh K. Puthan, Parag Deshpande, Vadakkanchery V. Vaidyanathan, Richard W. Gelling, Gaurav Patel, Tapas Das, Sathyavageeswaran Shreeram,