Alkali cation regulation of the dissociation and hydrobromination of a deprotonated trideoxynucleotide

▶ Alkali cation regulation of the gas-phase dissociation of the deprotonated trideoxycytoside dianion (CCC-2H)2− is measured by CID using ESI mass spectrometry. ▶ Sodium cation regulation of the gas-phase chemical reactivity of [Na(CCC-2H)]− anion with HBr is measured using ESI/SIFT/QqQ tandem mass spectrometry. ▶ Quantum chemical calculations (RI-MP2) provide structural and energetic results for the alkaliation and hydrobromination of (CCC-2H)2− and [M(CCC-2H)]− anions.