The amino terminus of cGMP-dependent protein kinase Iβ increases the dynamics of the protein's cGMP-binding pockets

▶ The N-terminus of PKG Iβ modulates cGMP-affinity in its cyclic nucleotide binding pockets. ▶ The N-terminus of PKG Iβ increases the dynamics of the nucleotide binding pockets. ▶ The increased dynamics may account for the increased cGMP-affinity.