Article ID Journal Published Year Pages File Type
7606144 International Journal of Mass Spectrometry 2011 8 Pages PDF
Abstract
▶ Capabilities of MS-based PLIMSTEX illustrated for calmodulin-peptide binding. ▶ Digestion of calmodulin following HDX reveals binding at component peptide level. ▶ The presence of peptide ligands increases Ca2+ binding affinity to calmodulin. ▶ Similar HDX patterns for binding of three peptides suggest common structures.
Keywords
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
Preview
Hydrophobic peptides affect binding of calmodulin and Ca2+ as explored by H/D amide exchange and mass spectrometry
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