| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7606191 | International Journal of Mass Spectrometry | 2011 | 10 Pages |
Abstract
ⶠFXIII can be activated both via a proteolytic pathway and a non-proteolytic pathway. ⶠWeakened dimer interaction is observed in rFXIIIaâ², rFXIIIa* and rFXIIIÃ¥. ⶠExtensive conformational changes occur upon full activation to either rFXIIIa* or rFXIIIÃ¥. ⶠBoth activation pathways of rFXIII produce similar activated conformations.
Keywords
ESICIDHEPESUPLC4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acidFXIIIHydrogen/deuterium exchangehydrogen–deuterium exchangeTransglutaminaseTransglutaminasescollision induced dissociationStructure–activity relationshipMass spectrometryFactor XIIIEnzyme activationmatrix assisted laser desorption/ionizationMALDIultra performance liquid chromatographyelectrospray ionization
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Mette Dahl Andersen, Johan Henrik Faber,