Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7606194 | International Journal of Mass Spectrometry | 2011 | 10 Pages |
Abstract
â¶ Amide H/D exchange to monitor intermediates in cAMP-dependent activation of PKA. â¶ cAMP binding to CNB-B partially disrupts R:C interface of PKA without dissociation. â¶ cAMP binding to CNB-B increases dynamics in interdomain helices. â¶ Basis for positive cooperativity in cAMP activation of PKA.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Balakrishnan Shenbaga Moorthy, Suguna Badireddy, Ganesh S. Anand,