Mathematical modeling of full feed depletion split-flow lateral-transport thin self-adjustable channels (FFD-SPLITT-SA)

The article contains a description of both the mathematical modeling of particles separation in self-adjustable channel for Split Flow Thin Cell Fractionation (SPLITT), and the channel design concept. The channel is designed to work in full feed depletion mode (FFD-SPLITT). By using different diameters of outlets, the channel has the ability to self-adjust the flow rates at the outlets. Moreover, in order to increase the throughput of the sample only one splitter, positioned at the end of the separation cell, was used. Channel construction, which is based on the SPLITT cell developed by J.C. Giddings, has an innovative approach. All the parameters affecting the separation are automatically tuned through modification of the channel structure, and that in turn stems from mathematical model based on fluid mechanics.