Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7608456 | Journal of Chromatography A | 2018 | 31 Pages |
Abstract
Magnetic molecularly imprinted polymers (MMIPs) were prepared for cocaine recognition by bulk polymerization in the presence of magnetic nanoparticles (MNPs). Two reagents (polyethylene glycol (PEG) and 3-(trimethoxysilyl)propyl methacrylate (V)) were used for MNPs modification. MMIPs were characterized and compared in terms of loading capacity, reusability, accuracy and precision for the extraction of cocaine from saliva samples. It was observed that V-MMIPs gave higher physical stability than PEG-MMIPs. Thus, V-MMIP were used for the analysis of cocaine users saliva. The developed procedure based on ion mobility spectrometry (IMS) provided limits of detection and quantification of 4 and 14â¯Î¼gâ¯Lâ1, respectively, and recoveries in cocaine free saliva samples spiked at 80, 270 and 560â¯Î¼gâ¯Lâ1 ranging from 80 to 99%. Results found by the proposed method were statistically comparable to those obtained by two reference procedures; a lateral flow immunoassay and an ultra-high performance liquid chromatography coupled with tandem mass spectrometry. Therefore, MMIP-IMS can be considered as a fast, selective and sensitive alternative to reference methods with affordable cost avoiding the requirement of skilled operator.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Aitor Sorribes-Soriano, Francesc Albert Esteve-Turrillas, Sergio Armenta, Ana Montoya, José Manuel Herrero-MartÃnez, Miguel de la Guardia,