Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7609543 | Journal of Chromatography A | 2017 | 32 Pages |
Abstract
A plot of the minimal resolutions was used to help identifying the factor levels leading to the highest resolution between consecutive peaks. The effects of the DoE factors were visualized in a way that is familiar to the analytical chemist, i.e. by simulating the resulting chromatogram. The mixture of an active ingredient and seven impurities was separated in less than eight minutes. The approach discussed in this paper demonstrates how SFC methods can be developed and optimized efficiently using simple concepts and tools.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Charlene Muscat Galea, David Didion, David Clicq, Debby Mangelings, Yvan Vander Heyden,