Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7609621 | Journal of Chromatography A | 2017 | 8 Pages |
Abstract
In this study, a novel solid phase extraction based on porous magnetic graphene oxide-cyclodextrin polymers (MGO-CD) was developed with aromatic linker and used for the simultaneous extraction and preconcentration of trace antiepileptic drugs in plasma. The characteristics of MGO-CD were assessed by Fourier transform infrared spectroscopy (FT-IR), Brunauer-Emmett-Teller surface areas (BET), Transmission Electron Microscope (TEM), Scanning Electron Microscope (SEM), X-ray diffraction (XRD) and vibrating sample magnetometer (VSM). Magnetic cyclodextrin polymeric material exhibited a high specific surface area (187 m2 gâ1), large pore volume (0.12 cm3 gâ1), good saturated magnetization (37.68 emu gâ1), and excellent dispersibility in aqueous solution. Various parameters influencing the extraction recovery of drugs were studied. The method exhibited good linearity in the range of 1-50 μg mLâ1, and the limit of quantitation of carbamazepine, phenytoin, diazepam was 11.89, 47.10 and 16.17 ng mLâ1, respectively. The recoveries of three antiepileptic drugs range from 78.49 to 100.93% with relative standard deviations less than 5.5%. These analytical results demonstrated that the proposed approach based on MGO-CD was applicable for analysis of antiepileptic drugs in plasma samples.
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Authors
Jingyi Zhang, Donghao Liu, Xiaoyan Meng, Yi Shi, Ruya Wang, Deli Xiao, Hua He,