Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7610597 | Journal of Chromatography A | 2016 | 6 Pages |
Abstract
MISER chromatographic analysis (Multiple Injections in a Single Experimental Run) using supercritical fluid chromatography (SFC) with pressurized carbon dioxide-based eluents is well suited to the high throughput analysis of enantiopurity. SFC is currently the preferred method for fast enantiopurity analysis, with analysis times of only a few seconds achievable in some cases. Injector programming using both the Agilent Infinity and Shimadzu Nexera UC instruments permitted MISER SFC experiments to be performed. Several case studies are presented, showcasing the power and versatility of the technique, with 'plate analysis times' (the time required for analysis of enantiopurity of 96 samples) of less than 33-34Â min achievable in the best cases.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Kerstin Zawatzky, Mirlinda Biba, Erik L. Regalado, Christopher J. Welch,