Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7614031 | Journal of Chromatography A | 2013 | 5 Pages |
Abstract
Determination of the charged state distributions of partially- and fully-substituted sulfoalkylated cyclodextrins was achieved using hydrophilic interaction liquid chromatography (HILIC). HILIC analysis of a spiked sample of the partially sulfopropylated cyclodextrins was achieved using a gradient to baseline resolve the charged states from â1 to â14. The fully-substituted CDs yielded a major peak with some trace impurities and the partially-substituted sulfopropylated cyclodextrins showed a wide range of charge states present in the mixture. Small changes in the structure of the cyclodextrins have a significant impact on the retention times of the various types of cyclodextrins investigated.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Michael Jaramillo, Daniel L. Kirschner, Zhipeng Dai, Thomas K. Green,