| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7614386 | Journal of Chromatography A | 2013 | 12 Pages |
Abstract
⺠A dataset of 82 drugs presenting very diverse physico-chemical properties was investigated. ⺠Five different polar stationary phases packed with sub-2 μm particles were tested. ⺠The Agilent Zorbax RRHD was the most versatile HILIC column packed with sub-2 μm particles. ⺠The nature of the stationary phase and mobile phase pH are the most important parameters for HILIC method development. ⺠Screening four different stationary phases and two pH appear to be the best initial step for successful HILIC method development.
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Authors
Aurélie Periat, Benjamin Debrus, Serge Rudaz, Davy Guillarme,