| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7614449 | Journal of Chromatography A | 2013 | 6 Pages |
Abstract
⺠A new variant of anion exchange chromatography is described. ⺠IgG is excluded to the void volume from pH 3-10 and 0-4 M NaCl. ⺠Exclusion depends on a variable size exclusion effect mediated by grafted ligands. ⺠Most host cell proteins follow typical pH and salt trends for anion exchange. ⺠Greater than 99% reduction of all major contaminants is achieved in a single step.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Rui Nian, Cindy Chuah, Jeremy Lee, Hui Theng Gan, Sarah Maria Abdul Latiff, Wan Yee Lee, Vincent Vagenende, Yuan-Sheng Yang, Pete Gagnon,