Article ID Journal Published Year Pages File Type
7614552 Journal of Chromatography A 2012 9 Pages PDF
Abstract
► A mixed-mode SEC separation resolved a Trp oxidized variant of a Mab. ► The Trp oxidized species showed reduced potency. ► The quantitative capability of the method for measuring Trp oxidation was demonstrated.
Keywords
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
Preview
Facile method of quantification for oxidized tryptophan degradants of monoclonal antibody by mixed mode ultra performance liquid chromatography
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