| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7614814 | Journal of Chromatography B | 2018 | 34 Pages |
Abstract
- The first LC-MS/MS method for the simultaneous quantitation of MET, RIF and INH.
- The method requires 20â¯Î¼l of plasma and a short sample run time of 4â¯min.
- HILIC chromatography was used to separate small polar and hydrophobic compounds.
- The method was applied to a bioavailability study in rats.
- Co-administration of RIF and INH increased the bioavailability (AUC) of MET.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Katya Govender, John H. Adamson, Peter Owira,