| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7614978 | Journal of Chromatography B | 2018 | 34 Pages |
Abstract
- We present a validated UHPLC-HRMS method used for pharmacokinetic analysis of donepezil and its three structural “fragments”.
- One of the fragments accumulates in the brain, while two of them do not.
- This fragment could be responsible for active transport of donepezil and related compounds across the blood-brain barrier.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Jana Zdarova Karasova, Vit Sestak, Jan Korabecny, Eva Mezeiova, Vladimir Palicka, Kamil Kuca, Martin Mzik,