Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7615146 | Journal of Chromatography B | 2018 | 10 Pages |
Abstract
To prevent the formation of the clusters by avoiding methanol as modifier might be difficult, as this is a widely used modifier providing good solubility when analyzing polar compounds in SFC. A sample preparation with e.g. LLE would remove the alkali ions, however also introducing a time consuming and discriminating step into the method. Since the alkali metal ions were retained and affected by chromatographic adjustments as e.g. mobile phase modifications, a way to avoid them could therefore be chromatographic tuning, when analyzing samples containing them.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Alfred Haglind, Mikael Hedeland, Torbjörn Arvidsson, Curt E. Pettersson,