Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7616912 | Journal of Chromatography B | 2015 | 11 Pages |
Abstract
Most signal suppression effects were detected in the first half of the chromatographic run-time for the matrix extracts of urine and wastewater. The observed effects are caused by high mass flow of salts and other diverse matrix components that were contained in high concentrations in those biological matrices. We also found signal suppression in the matrix effect profile of plasma samples over a wide time range during the chromatographic separation that were associated with a high content of triglycerides of diverse carbohydrate chain lengths. Here, we provide a broader picture of how 33 substances were influenced during analysis. Our results imply that a high number of the investigated substances had comparable effects of matrix compounds, despite differences in their chemical structure.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Julia Rossmann, Robert Gurke, Lars David Renner, Reinhard Oertel, Wilhelm Kirch,