Article ID Journal Published Year Pages File Type
7618542 Journal of Chromatography B 2012 8 Pages PDF
Abstract
► A HPLC-UV method was developed for assaying dapivirine in biological matrices. ► Box-Behnken experimental design was successfully used to optimize the method. ► Validation according to FDA and EMA guidelines on bioanalytical assays was performed. ► Method was applied to cell-based/mucosal tissues uptake and permeability assays.
Keywords
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
Preview
Development and validation of a HPLC method for the assay of dapivirine in cell-based and tissue permeability experiments
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