Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7619157 | Journal of Chromatography B | 2012 | 8 Pages |
Abstract
⺠The combination of microdialysis and CZE and laser induced fluorescence detection (LIFD) for agmatine has not been attempted before. ⺠We used capillary zone electrophoresis and laser induced fluorescence detection (CZE-LIFD) to measure nanomolar concentrations of agmatine in submicroliter sample volumes. ⺠This analytical technique proved to detect 0.49 attomole of agmatine improving the sensitivity of previous analytical techniques. ⺠We successfully applied the technique to measure agmatine in brain dialysates from the hippocampus where agmatine acts as a putative neurotransmitter.
Related Topics
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Authors
Luis Betancourt, Pedro Rada, Daniel Paredes, Luis Hernández,