| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7619219 | Journal of Chromatography B | 2012 | 8 Pages |
Abstract
⺠Binding of drugs to plasma proteins can be stereoselective. ⺠Unbound concentrations of tramadol, M1 and M2 enantiomers were analyzed by MS/MS. ⺠Kinetics of tramadol and M2 was enantioselective in patients with neuropathic pain. ⺠Fraction unbound of tramadol enantiomers was higher than that of the (+)-M1.
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Authors
Natália Valadares de Moraes, Gabriela Rocha Lauretti, Marcio Nogueira Napolitano, Naiane Ribeiro Santos, Ana Leonor Pardo Campos Godoy, Vera Lucia Lanchote,