Mass spectrometry characterization of DOTA-Nimotuzumab conjugate as precursor of an innovative Î²â tracer suitable in radio-guided surgery

Article ID	Journal	Published Year	Pages	File Type
7626271	Journal of Pharmaceutical and Biomedical Analysis	2018	23 Pages	PDF

Keywords

DDS TFA AMBIC ACN DTT BPb FDR IAA RGS dl-dithiothreitol CID mAb BFCA EGFR m/z nim Monoclonal antibody Acetonitrile Trifluoroacetic acid Formic acid Bromophenol Blue Lysine residues Ammonium bicarbonate Tris-HCl collision induced dissociation Radio-guided surgery Tumor resection Retention time antibody light chain Mass spectrometry Bifunctional chelating agent LYS Conjugate false discovery rate Nimotuzumab Mass-to-charge ratio Molecular weight Monoclonal antibodies epidermal growth factor receptors iodoacetamide

Related Topics

Physical Sciences and Engineering Chemistry Analytical Chemistry

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Mass spectrometry characterization of DOTA-Nimotuzumab conjugate as precursor of an innovative Î²â tracer suitable in radio-guided surgery

Authors

Claudia Martelli, Valeria Marzano, Federica Marini, Teresa Scotognella, Ilaria Fratoddi, Iole Venditti, Dante Rotili, Elena Solfaroli-Camillocci, Francesco Collamati, Carlo Mancini-Terracciano, Silvio Morganti, Daria Maccora, Riccardo Faccini,