Effective phospholipids removing microelution-solid phase extraction LC-MS/MS method for simultaneous plasma quantification of aripiprazole and dehydro-aripiprazole: Application to human pharmacokinetic studies

Article ID	Journal	Published Year	Pages	File Type
7627037	Journal of Pharmaceutical and Biomedical Analysis	2018	10 Pages	PDF

Keywords

SRM SPE PPT CyP EMA PFP LLE HLB DAD MRM CID LC-MS tmax ESI LLOQ TIC ARI pentafluorophenyl Cmax FDA XIC AUC LC-MS/MS t1/2 Aripiprazole European Medicines agency EDTA Ethylenediaminetetraacetic acid Collision-induced dissociation US Food and Drug Administration internal standard Calibration standard Solid phase extraction Liquid-liquid extraction Supported liquid extraction Ultraviolet standard deviation Protein precipitation diode array detection hydrophilic-lipophilic balance lower limit of quantification maximum plasma concentration standard error of mean Antipsychotics Retention time Cytochrome P450 Coefficient of Variation Correlation coefficient Liquid chromatography-mass spectrometry Liquid chromatography-tandem mass spectrometry Pharmacokinetics SLE SEM area under curve selected ion monitoring Multiple-reaction monitoring Half-life cal HPLC high-performance liquid chromatography total ion chromatogram quality control electrospray ionization

Related Topics

Physical Sciences and Engineering Chemistry Analytical Chemistry

Effective phospholipids removing microelution-solid phase extraction LC-MS/MS method for simultaneous plasma quantification of aripiprazole and dehydro-aripiprazole: Application to human pharmacokinetic studies

Authors

Aneta Wojnicz, Carmen Belmonte, Dora Koller, Ana Ruiz-Nuño, Manuel Román, Dolores Ochoa, Francisco Abad-Santos,