Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7627387 | Journal of Pharmaceutical and Biomedical Analysis | 2018 | 18 Pages |
Abstract
DNA binding of the drug was confirmed by shifts in the characteristic CD bands of the DNA, the appearance of an induced CD (ICD) signal in the upper absorption region of sunitinib (300â¯nm-500â¯nm), and the evidence from CD melting studies and the NMR. Based on the CD and NMR measurements, it can be assumed that sunitinib has a multiple-step binding mechanism.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Eszter Kiss, Arash Mirzahosseini, Ágnes Hubert, Attila Ambrus, László Årfi, Péter Horváth,