Development and validation of a sensitive and rapid UHPLC-MS/MS method for the simultaneous quantification of the common active and inactive metabolites of vicagrel and clopidogrel in human plasma

Article ID	Journal	Published Year	Pages	File Type
7627694	Journal of Pharmaceutical and Biomedical Analysis	2018	38 Pages	PDF

Keywords

Cmax ULOQ P2Y12 inhibitor MPB ISR MRM UHPLC EMA RSD ESI LLOQ AUC LC–MS/MS MS/MS European Medicines agency EDTA Ethylenediaminetetraacetic acid Matrix effect internal standard relative standard deviation incurred sample reanalysis upper limit of quantification lower limit of quantification maximum plasma concentration relative error Tandem mass spectrometry matrix factor active metabolite area under the concentration–time curve multiple reaction monitoring Human plasma liquid chromatography high performance liquid chromatography Ultra-high-performance liquid chromatography HPLC clopidogrel quality control electrospray ionization

Related Topics

Physical Sciences and Engineering Chemistry Analytical Chemistry

Development and validation of a sensitive and rapid UHPLC-MS/MS method for the simultaneous quantification of the common active and inactive metabolites of vicagrel and clopidogrel in human plasma

Authors

Cai Liu, Youming Lu, Hongbin Sun, Jin Yang, Yongqiang Liu, Xiaojuan Lai, Yanchun Gong, Xuefang Liu, Yongguo Li, Yifan Zhang, Xiaoyan Chen, Dafang Zhong,