Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7627785 | Journal of Pharmaceutical and Biomedical Analysis | 2018 | 22 Pages |
Abstract
Many novel antivirals against hepatitis C virus (HCV) and HIV have been introduced into the clinical practice over the last decade. The recent broadening portfolio of these groups of antivirals is reflected in increasing number of developed analytical methods required to meet the needs of clinical terrain. Part II summarizes the mechanisms of action of antivirals against hepatitis B virus (HBV), HCV, and HIV, their use in clinical practice, and analytical methods for individual classes. It also provides expert opinion on state of art in the field of bioanalysis of these drugs. Analytical methods reflect novelty of these chemical structures and use by far the most current approaches, such as simple and high-throughput sample preparation and fast separation, often by means of UHPLC-MS/MS. Proper method validation based on requirements of bioanalytical guidelines is an inherent part of the developed methods.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Lucie Nováková, Jakub PavlÃk, Lucia Chrenková, OndÅej Martinec, LukáÅ¡ Äervený,