| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7627919 | Journal of Pharmaceutical and Biomedical Analysis | 2018 | 34 Pages |
Abstract
Cannabis products have recently regained much attention due to the high pharmacological potential of their cannabinoid content. In this review, the most widely used sample preparation strategies for the extraction of cannabinoids are described for the specific application to either plant materials or biological matrices. Several analytical techniques are described pointing out their respective advantages and drawbacks. In particular, chromatographic methods, such as TLC, GC and HPLC, are discussed and compared in terms of selectivity and sensitivity. Various detection methods are also presented based on the specific aim of the cannabinoids analysis. Lastly, critical considerations are mentioned with the aim to deliver useful suggestions for the selection of the optimal and most suitable method of analysis of cannabinoids in either biomedical or cannabis derived samples.
Keywords
NCIESIHS-SPMELOQCPELLEAPCIHPTLCPLESFECyclohexaneDCMCBDCBNSPEEtOHACNTLCCBDACBGATHCABSTFADADCBEAcOHUPLCQ-TOFHFIPCBVhexafluoroisopropanolCBCCBGFLDTHCVEtOAcCHCl3TFAATMCsCBDVR.T.QqQMSTFATHC-COOHNH4OHCBCAcblAiPrOHPFPAEt2Ocannabichromenic acido.n.Pentafluoropropionic anhydridehigh performance TLCnuclear magnetic resonance1H NMRcannabigerolHeadspace solid phase microextractionProton NMRN,O-bis(trimethylsilyl)trifluoroacetamideΔ9-Tetrahydrocannabinoldiode array detectorflame ionization detectorAmmonium hydroxideTrifluoroacetic anhydrideEthanolEthyl acetateSolid-liquid extractionSupercritical fluid extractionSolid phase extractionLiquid-liquid extractionPressurized Liquid ExtractionCloud point extractionAcetonitrileAcetic acidFormic acidCannabidiolic acidCannabigerolic acidUltravioletIsopropanolElectron impactTrimethylchlorosilaneNMRIon trapLOD یا Limit of detectionFIDRoom temperatureDiethyl etherDichloromethaneCBTQuadrupole-time of flightCannabisMass spectrometryFT-IRFourier transform infrared spectroscopyfluorescence detectorFUSESLEOral fluidsMethanollimit of quantificationlimit of detectionReverse phaseMeOHMEPsChemiluminescenceHexhexaneHILICTriple quadrupolecannabidivarinCannabidiolCannabinoidscannabinolcannabichromenethin layer chromatographyliquid chromatographyHPLCGas chromatographyChloroformCblelectrospray ionizationatmospheric pressure chemical ionizationNegative chemical ionizationovernight
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Cinzia Citti, Daniela Braghiroli, Maria Angela Vandelli, Giuseppe Cannazza,