An integrated approach for profiling oxidative metabolites and glutathione adducts using liquid chromatography coupled with ultraviolet detection and triple quadrupole-linear ion trap mass spectrometry

Article ID	Journal	Published Year	Pages	File Type
7628594	Journal of Pharmaceutical and Biomedical Analysis	2016	10 Pages	PDF

Keywords

GSH PIF HLM EPI HRMS EMS RLM MRM NAC NLF NADPH EMC SPE DMPK QTrap Multiple ion monitoring LC/MS N-acetylcysteine Solid phase extraction Neutral loss scan Precursor ion scan Ultraviolet enhanced product ion scan High resolution mass spectrometry Reactive metabolite MIM EIC human liver microsome rat liver microsome multiple reaction monitoring Liquid chromatography/mass spectrometry extracted ion chromatography Glutathione

Related Topics

Physical Sciences and Engineering Chemistry Analytical Chemistry

An integrated approach for profiling oxidative metabolites and glutathione adducts using liquid chromatography coupled with ultraviolet detection and triple quadrupole-linear ion trap mass spectrometry

Authors

Guiying Chen, Zhongzhe Cheng, Kerong Zhang, Hongliang Jiang, Mingshe Zhu,