Simultaneous quantification of PGI2 and TXA2 metabolites in plasma and urine in NO-deficient mice by a novel UHPLC/MS/MS method

Article ID	Journal	Published Year	Pages	File Type
7628612	Journal of Pharmaceutical and Biomedical Analysis	2016	7 Pages	PDF

Keywords

LLOQ Ultra-fast liquid chromatography FDA Thromboxane A synthase UHPLC/MS/MS EtOAc PGIS PGI2 TXB2 CXP TXS TxA2 PLA2 UFLC MRM COX-1 COX-2 EtOH EMA ACN l-NAME Nω-nitro-l-arginine methyl ester phospholipase A2 European Medicines agency Ethanol Ethyl acetate internal standard Acetonitrile Acetic acid Formic acid collision energy eicosanoids thromboxane B2 Thromboxane A2 lower limit of quantification Food and Drug Administration Prostacyclin synthase cyclooxygenase-1 Cyclooxygenase-2 multiple reaction monitoring Nitric oxide declustering potential collision cell exit potential entrance potential prostacyclin

Related Topics

Physical Sciences and Engineering Chemistry Analytical Chemistry

Simultaneous quantification of PGI2 and TXA2 metabolites in plasma and urine in NO-deficient mice by a novel UHPLC/MS/MS method

Authors

Agnieszka Kij, Lukasz Mateuszuk, Barbara Sitek, Kamil Przyborowski, Agnieszka Zakrzewska, Krystyna Wandzel, Maria Walczak, Stefan Chlopicki,