Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7628773 | Journal of Pharmaceutical and Biomedical Analysis | 2016 | 33 Pages |
Abstract
Herbal medicine has been proven to be an effective therapy offering a variety of benefits, such as moderate reduction in hypoglycemia, in the treatment and prevention of obesity and diabetes. Phyllanthus niruri has been used as a treatment for diabetes mellitus. Herein, the induction of type 2 diabetes in Sprague-Dawley rats was achieved by a low dose of streptozotocin (STZ) (25 mg/kg bw). Here, we evaluated the in vivo antidiabetic properties of two concentrations (250 and 500 mg/kg bw) of P. niruri via metabolomics approach. The administration of 500 mg/kg bw of P. niruri extract caused the metabolic disorders of obese diabetic rats to be improved towards the normal state. The extract also clearly decreased the serum glucose level and improved the lipid profile in obese diabetic rats. The results of this study may contribute towards better understanding the molecular mechanism of this medicinal plant in managing diabetes mellitus.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Ahmed Mediani, Faridah Abas, M. Maulidiani, Alfi Khatib, Chin Ping Tan, Intan Safinar Ismail, Khozirah Shaari, Amin Ismail, N.H. Lajis,