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Stability-indicating reversed-phase HPLC method development and characterization of impurities in vortioxetine utilizing LC-MS, IR and NMR

Article ID Journal Published Year Pages File Type
7629160 Journal of Pharmaceutical and Biomedical Analysis 2016 27 Pages PDF
Keywords
ESIRRTSMCACNSMB%RSDAcetonitrilerelative standard deviationStructural elucidationSMARegressionRelative retention timeElectrospray ionization sourceProcess-related impuritiesResolutionVortioxetineQuantification
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
Preview
Stability-indicating reversed-phase HPLC method development and characterization of impurities in vortioxetine utilizing LC-MS, IR and NMR
Authors
Lei Liu, Na Cao, Xingling Ma, Kaihe Xiong, Lili Sun, Qiaogen Zou, Lili Yao,
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Journal
Journal of Pharmaceutical and Biomedical Analysis
Journal: Journal of Pharmaceutical and Biomedical Analysis
Related Categories
ESI
RRT
SMC
ACN
SMB
%RSD
Acetonitrile
relative standard deviation
Structural elucidation
SMA
Regression
Relative retention time
Electrospray ionization source
Process-related impurities
Resolution
Vortioxetine
Quantification
Analytical Chemistry
Chemistry (General)
Electrochemistry
Inorganic Chemistry
Organic Chemistry
Physical and Theoretical Chemistry
Spectroscopy
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