| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7629586 | Journal of Pharmaceutical and Biomedical Analysis | 2015 | 34 Pages |
Abstract
- API fingerprinting based on chromatographic purity profile was done.
- Differentiation features of morphine LC/MS & LC/DAD impurity profile were captured.
- LC/MS gives broad analytical window for supervised pattern recognition techniques.
- Different origin of morphine sulfate and morphine base can be detected.
Keywords
MDAMOSCPPPLSPRTCDAFDFSIMCATFAAPIHCAMOBPCATrifluoroacetic acidHierarchical cluster analysisMultivariate data analysisPrincipal component analysistriethanolaminePattern recognition techniquesPartial least square regressionMass spectrometryMethanolSoft independent modeling of class analogyActive Pharmaceutical Ingredientmorphinemorphine sulfateMorphine hydrochlorideMeOHMoHTEAChemometrics
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Jelena Acevska, Gjoshe Stefkov, Ivana Cvetkovikj, Rumenka Petkovska, Svetlana Kulevanova, JungHwan Cho, Aneta Dimitrovska,