| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7629771 | Journal of Pharmaceutical and Biomedical Analysis | 2015 | 6 Pages |
Abstract
- The metabolism of gentiopicroside in rats was studied by LC/MS following precolumn derivatization.
- The main metabolite erythrocentaurin and gentiopicral were detected in rat plasma.
- The monoterpene compound gentiopicroside was found to be metabolized to dihydroisocoumarin in vivo.
- Methyl 4-formylbenzoate was used as the internal standard to quantify erythrocentaurin and gentiopicral in rat plasma.
- The metabolic pathway of gentiopicroside to erythrocentaurin and gentiopicral in vivo was proposed.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Zhigang Wang, Shuhan Tang, Yan Jin, Yan Zhang, Masao Hattori, Hailong Zhang, Ning Zhang,