| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7629910 | Journal of Pharmaceutical and Biomedical Analysis | 2015 | 7 Pages |
Abstract
- This is the first paper to report a bioanalytical method of perampanel (Fycompa®).
- Perampanel assay in human plasma was developed using LC-MS/MS.
- The validation study showed the method is simple, sensitive, and reproducible.
- This method was successfully applied to clinical bioanalysis.
- This method can be useful for therapeutic drug monitoring of perampanel.
Keywords
MRTLQCpeak area ratioMQCULOQHQCarea under the first moment curveAUMCtmaxISRAMPAEMARSDCmaxAEDLLOQAUCLC–MS/MSt1/2European Medicines agencyinternal standardValidationrelative standard deviationsincurred sample reanalysisEpilepsyParupper limit of quantificationlower limit of quantificationmaximum plasma concentrationrelative erroranti-epileptic drugstime to reach CmaxPharmacokineticsarea under the plasma concentration–time curveMean residence timeHalf-lifePerampanelPlasmaLiquid chromatography with tandem mass spectrometryHPLChigh-performance liquid chromatographyquality control
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Yuji Mano, Osamu Takenaka, Kazutomi Kusano,