| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7630296 | Journal of Pharmaceutical and Biomedical Analysis | 2015 | 8 Pages |
Abstract
- Validation of a selective and sensitive HPLC-MS/MS assay for DETC-NAC is described.
- DETC-NAC is confirmed as a metabolite of disulfiram.
- Microdialysis studies demonstrate that DETC-NAC can cross the blood-brain barrier.
- Results discussed in the context of disulfiram use as a putative addiction treatment.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Robert D. Winefield, Anthonius A.M. Heemskerk, Swetha Kaul, Todd D. Williams, Michael J. Caspers, Thomas E. Prisinzano, Elinore F. McCance-Katz, Craig E. Lunte, Morris D. Faiman,