| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7630574 | Journal of Pharmaceutical and Biomedical Analysis | 2015 | 8 Pages |
Abstract
- We develop and validate a LC-MS/MS method to quantify TB drugs and metabolites.
- The method passes FDA guidance on bioanalytical method development.
- We apply the method in a pharmacokinetic study of healthy volunteers.
- The methodology enables a better understanding of the TB drug metabolism profiling.
- The methodology provides a way of phenotyping the acetylation of isoniazid.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Kim H. Hee, Jerold J. Seo, Lawrence S. Lee,